We are looking for a highly motivated candidate to join our team in developing the first bio-mimetic skeletal muscle model. This ANR project coordinated by UMR-INSERM1167 is based on clinical data from intensive care patients hospitalized for sepsis and seeks to recreate a tissular environment as close as possible to physiological reality.
Our goal is to better understand and treat muscle dysfunctions associated with critical conditions, and we are looking for a candidate who shares this vision and is eager to make a difference in the field of biomedical research.
Main tasks:
1. Development of a 3D Bio-mimetic Muscle Model
- Design and engineering of a cutting-edge three-dimensional model
2. Use of Human Primary Cells
- Cells will be obtained from human muscle biopsies (RIPH2)
3. Measurement of Mitochondrial Parameters and Muscle Contraction
- In-depth assessment of mitochondrial functions and muscle performance
4. Testing Pharmacological Inhibitors
- Rigorous evaluation of potential treatment efficacy
This innovative human bio-mimetic muscle project represents a significant breakthrough in the understanding of critical muscle diseases. It also opens up new opportunities for the development of personalized and effective treatments, making it an exciting challenge for anyone motivated about advancing biomedical science.
Required Technical Skills:
- Cell culture
- Tissue engineering and bio-printing
- High-resolution mitochondrial respiration measurement
- Immunofluorescence, western blot, RT-qPCR
- Muscle contraction analysis
Soft Skills and Motivation:
- Teamwork: Ability to collaborate effectively with multidisciplinary teams including clinicians, researchers.
- Dynamism: A proactive attitude and enthusiasm for tackling complex scientific challenges.
- Rigor and Autonomy: Precision in experimental work and the capacity to independently drive research forward.
- Interest for Biomedical Research: Above all, we are seeking a candidate who is genuinely motivated by the
potential impact of this project. The ideal candidate will demonstrate a strong desire to contribute to advancing
treatments for critical muscle diseases and to be part of a groundbreaking initiative.
Job Details:
- Contract: 1 year, renewable once
- Work environment: Inserm Lille, Medical school
Application:
Applications should include a detailed CV, a cover letter, relevant publications and 2 academic references.
Applications should be sent to Pr Lancel: steve.lancel@univ-lille.fr