Scientific Program

Time: Western European Time (Canary Islands local time)

Wednesday 26th January

09.00 - 09.30Welcome Ceremony
Vice-rector of the University of La Laguna (ULL)
Ben Boyd (CRS President)
Carmen Évora (SPLC-CRS President)
Bruno Sarmento (SPLC-CRS Vice president)
09.30 - 10.15

Ben Boyd
University of Copenhagen, Denmark, and Monash University, Australia.
"Metabolic labelling as a potential new approach to localised drug delivery"

Moderator: María Jesús Vicent (Príncipe Felipe Research Center, Valencia)

SESSION 1. Technological Tools in Advanced Drug Delivery Systems

Moderator: Bruno Sarmento. University of Porto

10.15 - 10.45Invited speaker
Nuno Azevedo
Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE). Faculty of Engineering. University of Porto. Portugal.
“Delivery of nucleic acid mimics into bacteria”
10.45 - 11.45

Short talks (10 min + 5 min questions)

"Protamine nanoparticles as non-viral vectors for gene-delivery in the treatment of glioblastoma"
S. Barrios-Esteban, R. Rahman, C. Alexander, M. Garcia-Fuentes and N. Csaba, Universidade de Santiago de Compostela.

"Dexamethasone and melatonin co-loaded PLGA microspheres: potential chronic neuroprotective strategy for glaucoma"

M. Brugnera; M. Vicario-de-la-Torre; V. Andrés-Guerrero; I. Bravo-Osuna; I.T. Molina-Martinez and R. Herrero-Vanrell, Complutense University of Madrid.

“Peptide nano-vaccine against SARS-CoV-2 infection”

R.C. Acúrcio, R. Kleiner, B. Carreira, D. Vaskovich, Y. Liubomirski, E. Yeini, C. Araújo, C. Plama, A.S. Viana, J. Gonçalves, R. Satchi-Fainaro, H.F. Florindo. University of Lisbon

“Smart targeted nanohybrids as dual-approach drug delivery systems against colorectal cáncer”

J. Gonzalez-Valdivieso, R. Vallejo, A. Girotti, S. Rodriguez-Rojo, Mercedes Santos, F.J. Arias. University of Valladolid.

11.45 - 12.15Break

12.15 - 13.30

Posters Session (2-3 min each + 10-15 min for questions)

Optimization of PLGA/PEI nanoparticles covered with poly(I:C) for cancer immunotherapy.
L. González-Melero. University of Basque Country

Amoebicidal Effect of Pitavastatin Nanoparticles in Acanthamoeba castellani Neff.
A. Oliva. Universidad de La Laguna.

Cell-free synthesis of Ebola virus matrix protein VP40 Virus-like particles.
S. Gutiérrez-Gutiérrez. Santiago de Compostela.

Chamomilla pollen microcapsules as multistep delivery systems.
L. Valverde-Fraga. Universidade de Santiago de Compostela.

Gone with the Waste - Quantification of the exact composition of polymeric nanocapsules.
G. Berrecoso. Universidade de Santiago de Compostela.

Infliximab microencapsulation by Coaxial Ultrasonic Atomization preserves its biological activity: in vitro evaluation.
I. Lamela-Gómez. Universidade de Santiago de Compostela.

Carvacrol-loaded microcapsules by a coaxial method for varroosis control. Effective parameters on their production.
A. Luzardo-Álvarez. Universidade de Santiago de Compostela.

Mucoadhesive buccal formulations based on lyophilized liposomes: application to sildenafil citrate.
A. Sánchez Navarro. Universidad de Salamanca

Development and study of liposomal formulation for nail administration of cyclopirox.
F.J. Otero Espinar. Universidade de Santiago de Compostela.

Development of a liposomal formulation containing Cyclosporin A for the treatment of dry eye disease.
M.A. González-Cela Casamayor. Complutense University of Madrid.

Budesonide microparticles for ocular administration.
M. Guzmán-Navarro. University of Alcalá.

: Luísa Corvo (University of Lisbon)

13.30 - 15.00Time for Lunch
15.00 - 16.25

Posters Session (2-3 min each + 10-15 min for questions)

New treatment for fungal keratitis: A combined eye drops of two antifungals.
V. Díaz-Tomé. Universidade de Santiago de Compostela

Bevacizumab-loaded PLGA intravitreal implants prepared by supercritical fluid technology.
C. Bendicho-Lavilla. Universidade de Santiago de Compostela.

Bevacizumab loaded lipidic lyotropic liquid crystals as a promising platform for ocular diseases.
G. Blanco-Fernández. Universidade de Santiago de Compostela.

Development of surface-modified lipid-polymer hybrid nanoparticles: bulk formulation vs microfluidics.
E. Briffault. Universidad de La Laguna.

Microfluidics for precise tuning of cubosome nanoparticle size.
C.J.O. Ferreira. University of Minho.

Characterization and in vivo evaluation of quercetin-loaded zein nanoparticles.
R. Campión. University of Navarra.

A Nanotechnology-based Immunotherapeutic Strategy Against KRAS mutated Colorectal Adenocarcinoma.
F. Andrade. Vall d'Hebron Institut de Recerca.

Self-Illuminating Biocompatible Nanosystems can Induce Apoptosis Via Photodynamic Therapy (PDT).
M. Abal-Sanisidro. Health Research Institute of Santiago de Compostela (IDIS).

Evaluation of Eudragit S100 Nanofibers as pH responsive antimicrobial release system.
L. Miranda-Calderón. Universidad de Zaragoza.

Nucleic acid based medicinal products for Fabry disease: critical formulation factors to ensure effective delivery.
I. Gómez-Aguado. University of Basque Country.

Fluorescence Cross-Correlation Spectroscopy reveals extent of association between liposomes and DNA and the number of DNA molecules per lipid nanoparticle.
B.F.B. Silva. INL - International Iberian Nanotechnology Laboratory.

DOSY as an Alternative Technique to Monitor the Degradation of Polypeptide-Based Drug Delivery Systems.
M.J. Vicent. Centro de Investigación Príncipe Felipe.

: Rosa Mª Hernández (University of the Basque Country).

16.25 - 17.00

PhD Thesis Award sponsored by Bial

Moderator: Rocío Herrero (University Complutense de Madrid)

17.00 - 18.00Interactive Session with Prof. Jesús Santamaría.
University of Zaragoza.
“A PhD degree and Beyond. Thoughts for early-career researchers”

Time: Western European Time (Canary Islands local time)

Thursday 27th January

09.00 - 09.45

Camilla Foged
Department of Pharmacy. Vaccine Design and Delivery Group. University of Copenhagen. Denmark
"Opportunities and challenges in the delivery of mRNA vaccines"

Moderator: María Blanco (University of Navarra)

SESSION 2. Biomimetic Structures for Diagnosis and Therapy

Moderator: Susana Simões. Centre for Innovative Biomedicine and Biotechnology (CBB). University of Coimbra

09.45 - 10.15Invited speaker
Pieter Vader
CDL Research and Department of Experimental Cardiology. University Medical Center (UCM) Utrecht. Netherlands.
“Extracellular vesicle-mediated RNA delivery: From mechanistic insights to therapeutic applications”
10.15 - 11.15

Short Talks (10 min + 5 min questions)

"Functionalization of a meniscus prosthesis with polymeric coatings for the sustained release of anti-inflammatory drugs"
A. Fernandez Blanco, G. Lou, J. C. Campo, M. J. Alonso, Universidade de Santiago de Compostela.

"Exosome-mediated MEK1 silencing is a promising approach against triple negative breast cancer regression"

D. Ferreira, C. Santos-Pereira, M. Costa, J. Afonso, A. Longatto-Filho, F. Baltazar, R. Kalluri, J. Moreira and L.R. Rodrigues, University of Minho.

“Etoposide and edelfosine lipid nanomedicines as a synergistic combination therapy for neuroblastoma”

SH. El Moukhtari, G.M. Pelin, M.J. Blanco-Prieto, University of Navarra.

“Pollen-based platforms for pulmonary delivery of nanoencapsulated rifabutin”

S. Robla, J.M. Ageitos, R. Ambrus, N. Csaba, Universidade de Santiago de Compostela.

11.15 - 11.30

Posters Session (2-3 min each + 5 min for questions)

In vitro production, isolation and characterization of Ebola virus-like particles.
R. Mellid-Carballal. Universidade de Santiago de Compostela.

Self-assembling dendrimer for the delivery of antisense NAMs into bacteria.
M. Gomes. University of Porto.

Transtympanic delivery of the pneumoccal endolysin MSlys via PEGylated liposomes.
M. D. Silva. University of Minho.

11.30 - 12.00Break

SESSION 3. Innovative Strategies for Drug Targeting

Moderator: Helena Florindo. University of Lisbon

12.00 - 12.30Invited speaker
Jesús Santamaría
Department of Chemical and Environmental Engineering. Instituto de Nanociencia y Materiales de Aragon (INMA). University of Zaragoza
“Extracellular vesicles as selective vectors for delivery of nanomaterials to tumors”
12.30 - 13.45

Short Talks (10 min + 5 min questions)

"Lipid-based non viral gene therapy for Fabry disease:Ex vivo and in vivo evaluation"
J. Rodríguez-Castejón, I. Gómez-Aguado, M. Beraza-Millor, M.A. Solinís, A. del Pozo-Rodríguez and A. Rodríguez-Gascón, University of the Basque Country.

"Treating Neurodegeneration with Synergistic Combinations of Polypeptide-Based Nanoconjugates Targeting Oxidative Stress and Inflammation"

I. Conejos-Sánchez, E. Masiá, M.J. Vicent, Centro de Investigación Príncipe Felipe.

“Combining glucose-responsive nanoparticles and iPSCs differentiation: an innovative strategy to treat diabetes”

JM. Marques, A.M. Carvalho, R. Nunes, J. das Neves, H. Florindo, D. Ferreira, B. Sarmento, University of Porto.

“Multifunctional nanoparticles as an anticancer approach for the intracellular delivery of monoclonal antibodies”

A.M. López-Estévez, L. Sanjurjo, J. Pellico, R.T.M. de Rosales, D. Torres, and M.J. Alonso, Universidade de Santiago de Compostela.

“Non-viral delivery of CRISPR/Cas9 DNA for gene editing via multivalent cationic liposome system”

D.A. Sousa, R. Gaspar, J. O. Ferreira, F.Baltazar, B. Silva 2 and L.R. Rodrigues. University of Minho.

13.45 - 15.15Time for Lunch
15.15 - 16.20

Posters Session (2-3 min each + 10-15 min for questions)

Ultraflexible lipid vesicles allow in vitro skin permeability of Cyanocobalamin: a potential treatment for Vitamin B12 deficiency.
A.J. Guillot. University of Valencia.

Targeted cathelicidin nanomedicines as novel glucoregulator for diabetes therapy
C. Cristelo. University of Porto.

Preclinical basis of nanostructured lipid carriers (NLC) loaded with aflibercept: design, development and characterization.
X. García-Otero. Universidade de Santiago de Compostela.

Infliximab-loaded PLGA nanoparticles: design, development, and physicochemical characterization.
R. Varela-Fernández. Universidade de Santiago de Compostela.

Inulin-PCL nanoparticles as an adjuvant delivery system for highly purified recombinant antigens.
S. Jesus. University of Coimbra.

Using polypeptide-based nanoconjugates as mitochondrially-targeted drug delivery platforms.
C. Pegoraro. Centro de Investigación Príncipe Felipe.

Cannabinoid-loaded receptor-targeted nanoparticles improve anticancer activity through delayed cell internalization.
M. Durán-Lobato. Universidad de Sevilla.

3D printed tacrolimus suppositories for the treatment of ulcerative colitis.
I. Seoane-Viaño. Universidade de Santiago de Compostela.

: Alicia Rodríguez-Gascón (University of the Basque Country).

16.20 - 17.25

Posters Session (2-3 min each + 10-15 min for questions)

Development of shear-responsive microaggregates based on PLGA nanoparticles for targeted delivery.
L. Martin Banderas. Universidad de Sevilla.

Lipid-polymeric hybrid nanoparticles funcionalized with a specific aptamer: cellular uptake and citotocicity.
P. Díaz-Rodríguez. Universidade de Santiago de Compostela.

Organs toxicity of oligonucleotide aptamer-lipid-polymer nanoparticles for osteoporosis.
R. Reyes. Universidad de La Laguna.

Immunotoxicological properties of yeast-derived glucan particles.
J. Panão Costa. University of Coimbra.

The influence of curcumin-encapsulated glucan nanoparticles on oxidative stress in liver cells.
M. Colaço. University of Coimbra.

Preparation, characterization and efficacy of polylactide glycolide-chitosan nanoparticles loaded with Curcuma.
J. Molpeceres. University of Alcalá

Polymeric nanoparticles loaded anti-viral peptide efficiently inhibits SARS-CoV-2.
A. Mali. University of Luigi Vanvitelli and University of Santiago de Compostela.

Magnetic Targeting of a Novel Hybrid Nanosystem for Antitumoral Activity Enhancement.
N. Cruz. University of Lisbon.

:Bruno Silva (International Iberian Nanotechnology Laboratory, Braga).

Time: Western European Time (Canary Islands local time)

Friday 28th January

09.00 - 09.45

Álvaro Mata
Chair in Biomedical Engineering and Biomaterials. School of Pharmacy. University of Nottingham.
"Bioengineering biomimetic 3D environments and in vitro models through supramolecular self-assembly"

Moderator: Carmen Álvarez (University of Santiago de Compostela)

SESSION 4. Hydrogels and 3D Models for Drug Delivery Systems

Moderator: Patricia Díaz-Rodríguez. University of Santiago de Compostela

09.45 - 11.00

Short Talks (10 min + 5 min questions)

"Biocompatible Injectable Smart Hydrogels-based Depot Systems: A Dual-Anticancer Drug Sustained Release Strategy"
D. Rafael, F. Andrade, M.M. Roca-Melendres, D. Hide, I. Raurell, M. Martell, S. Schwartz, M. Oliva, E. Duran-Lara and I. Abasolo. Vall D'Hebron Institut de Recerca.

"Modulating muchoadhesion and mucopenetration in multiresponsive nanogels"

M. Calderón, S. Orellano, J. Udabe and A. Sonzogni. University of the Basque Country.

“Does it GUT what it takes? A new 3D bioengineered in vitro intestinal model to predict permeability”

M.H. Macedo, A.S. Barros, E. Martinez, C.C. Barrias, B. Sarmento, University of Porto.

“Uterine leiomyoma 3D preclinical model for local delivery testing”

P. García-García, A. Salas, C. Évora, P. Díaz-Rodríguez, T.A. Almeida and A. Delgado, Universidad de La Laguna

Evaluation of lipid nanosystems for cancer treatment in static and non-static 3D models

M. Cascallar, A. Martins, M. Ferrero, E. Escorihuela, S. Calabuig-Fariñas, L. Diéguez, E. Jantus-Lewintre, M. de la Fuente. Health Research Institute of Santiago de Compostela (IDIS)/CIBERONC

11.00 - 11.30Break
11.30 - 12.30

Posters Session (2-3 min each + 10-15 min for questions)

Carboxymethyl cellulose-based 3D scaffolds for wound healing.
C. Alvarez-Lorenzo. Universidade de Santiago de Compostela.

Gelatin hydrofilms with bioactive compounds Aloe vera and EGF for chronic wound healing applications.
I. Garcia-Orue. University of the Basque Country

A novel sumecton enriched gelatin-based scaffold for bone regeneration.
I. Lukin. University of Basque Country.

Extracellular vesicle-loaded hydrogel for stimulating cardiac repair after myocardial infarction.
E. Garbayo. University of Navarra.

Novel injectable thermosensitive hydrogel containing chitosan-dextran sulphate nanoparticles for antigen delivery.
E. Giuliano. University of Santiago de Compostela.

Functionalized hyaluronic acid-based hydrogel for ophthalmic application. Preliminary studies.
A. Aragón-Navas. Complutense University of Madrid.

Mucoadhesive nanoparticles for ocular delivery of ketorolac.
M. Oliva. Universitat de Barcelona.

Licensing hydrogels maintain the immunomodulatory phenotype of human mesenchymal stromal cells in a murine colitis model.
A. Gonzalez-Pujana. University of the Basque Country

: Dolores Torres (University of Santiago de Compostela).

SESSION 5. Young Scientist Networking

Moderators: Cláudia Martins (Univ. Porto), Souhaila El Moukhtari (Univ. Navarra), Mireya L. Borrajo (Univ. Santiago de Compostela) and Patricia García-García (Univ. La Laguna).

12.30 - 13.30

Short Talks (7 min + 3 min questions)

"Exploiting the chemotherapeutic and immunomodulatory effect of brain and glioblastoma dual-targeted nanoparticles – a nanomedicine, chemistry and tumor biology therapeutic recipe making use of a novel tumor niche-recapitulating 3D spheroid construct"
C. Martins, C.M. Barbosa, M. Araújo, S. J. Smith, M. J. Oliveira, D. Lamprou, R. Rahman, J. W. Aylott, B. Sarmento. University of Porto.

"Nanosystems for the development of mRNA vaccines"

M.L. Borrajo, S. Anthiya, G. Lou, and MJ. Alonso. University of Santiago de Compostela

“mRNA Reprograming Matrices for driving chondroblast differentiation in vitro and in vivo ”

H. Rilo-Alvarez, A. M. Ledo, M. Lopez-Peña, F. M. Muñoz, A. Vidal, M. Garcia- Fuentes. University of Santiago de Compostela

“Nanoclay-incorporated HA/alginate scaffolds as SDF-1 smart delivery-platforms for bone tissue engineering”

I. Erezuma, , I. Lukin, P. García-García, A. Delgado, R. Reyes , C. Evora and G. Orive. University of Basque Country.

“Extracellular vesicles from hair follicle and adipose tissue-derived mesenchymal stem cells: Flow cytometry characterization and functional comparison for the treatment of diabetic ulcers”

K. Las Heras, F. Royo, C. Garcia-Vallicrosa, M. Igartua, E. Santos-Vizcaino, J.M. Falcon-Perez, R Hernandez. University of Basque Country.

Direct powder extrusion 3D printing of polyhydroxybutyrate implants for prolonged drug release

S. Moroni, M. Tiboni, L. Casettari. University of Urbino

13.30 - 15.00Time for Lunch

FINAL SESSION. Discussion: Positive-negative aspects of brain targeted drug delivery systems

15.00 - 16.00

Jose Luis Lanciego vs Meritxell Teixidó

Jose L. Lanciego
Head of department of Neuroscience at the Center for Applied Medical Research (CIMA). University of Navarra.

Meritxell Teixidó
Chief Executive Officer/Chief Scientific Officer at Gate2Brain SL. Barcelona. Spain.

Moderator: M.J. Alonso (University of Santiago de Compostela)

16.00 - 16.30

Awards for the best oral communication and poster.

Closing ceremony

16.30 - 17.30General Assembly of the SPLC-CRS