In this presentation, Prof. Amiji will cover several of our approaches for development of multifunctional engineered nano-systems for targeted therapies in the treatment of cancer and inflammatory diseases. Specific examples will include: (1) CNS delivery of lipid modified analgesic peptide using oil-in-water nanoemulsion, (2) overcoming tumor multidrug resistance using a combinatorial-designed engineered nano-systems for RNAi and chemotherapy, and (3) genetic modulation of macrophage phenotype to promote anti-inflammatory effect in the treatment of rheumatoid arthritis.
In each of the above examples, they focus on challenging medical problems with innovative solutions that use safe materials and scalable fabrication methods in order to facilitate clinical translation and improve patient outcomes.
Dr. Mansoor Amiji, PhD in pharmaceutical sciences from Purdue University in 1992, is currently the University Distinguished Professor, Professor of Pharmaceutical Sciences, and Professor of Chemical Engineering at Northeastern University in Boston, MA.
Dr. Amiji’s research is focused on development of biocompatible materials from natural and synthetic polymers, target-specific drug and gene delivery systems for cancer and infectious diseases, and nanotechnology applications for medical diagnosis, imaging, and therapy. His research has received over $20 million in sustained funding from the NIH, NSF, private foundations, and the pharmaceutical/biotech industries. Dr. Amiji teaches in the professional pharmacy program and in the graduate programs of Pharmaceutical Science, Biotechnology, and Nanomedicine.
He has edited ten books and has published over 50 books chapters and over 250 peer-reviewed articles. He has received a number of honors and awards including the Nano Science and Technology Institute’s Award for Outstanding Contributions towards the Advancement of Nanotechnology, Microtechnology, and Biotechnology, American Association of Pharmaceutical Scientists (AAPS) Meritorious Manuscript Award, Controlled Release Society’s (CRS) Nagai Award, and the AAPS and CRS Fellowships.